Intended for researchers and those involved in research oversight, this activity provides an overview of ethical principles of biomedical research in global settings, with a special emphasis on research in low- and middle-income countries (LMICs). We will begin with an 8-principle framework for conducting ethical research, then examine areas requiring special attention, including:Determining ethical standards of care for the control arm of trials.Adapting the informed consent process to various ...

This course provides an overview of key ethical principles and regulatory frameworks for the conduct of research with human subjects. It is intended for researchers and those involved in research oversight. Course topics include:Historical evolution of the present system of research oversight in the United States.Foundational documents, including the Nuremberg Code and Belmont Report.The 8 core principles of ethical human research.Relevant regulations in the United States, including the revised ...

This course provides an overview of how clinicians and policymakers have approached the rationing of health care resources, as well as an ethical framework that can inform present and future rationing and resource allocation decisions. During the course, we delineate a system for ethically allocating resources based on 4 principles: - Treating people equally. - Favoring the worst off. - Maximizing total benefits. - Promoting and rewarding social usefulness. Content last ...

This course provides an overview of ethical principles relevant to the design of trials involving human subjects. Learners will review foundational study designs and design tools with a focus on ethical and regulatory considerations.Topics include:Differentiating between research and quality improvement.Observational and interventional designs.Randomization, blinding, and placebos.First-in-Human, or Phase I, trials.Cluster randomization.Comparative effectiveness research.There was no commercial ...

This course provides an overview of ethical concerns regarding conflicts of interest in biomedical research. It also offers several approaches to safeguarding against conflicts of interest and describes related federal policies. Intended primarily for researchers, the course: Explains what a conflict of interest is and why conflicts are problematic. Provides data and analysis regarding the extent of conflicts of interest in research. Assesses strategies for avoiding and remediatin...

Children's Roles in Medical Decisions explores the three primary ways in which older children and teenagers can influence or control their medical care. It examines the ethics and law of emancipated and mature minors, and describes the ethical and practical challenges of children’s assent. There was no commercial support used in the development of this educational activity.  Content last reviewed: March 9, 2022

This course offers an overview of the legal and ethical issues pertaining to a therapist’s duty to warn and protect in cases where a patient may commit violence. It begins with a discussion ofthe 1968 case of Tatiana Tarasoff, which established legal precedent for a duty to warn. Then, using illustrative examples and interview material, it surveys how different states implement the duty to warn and protect, provides a framework for determining when and how to intervene with a potentially ...